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After having cut through the integuments, together with the three muscles, the fascia transversalis was exposed, but with my hand gently passed between it and the muscle of the same name, I reached a point near the brim of the true pelvis, where the peritoneum leaves this fascia, to be reflected backward over the pelvic viscera. It is not very surprising that bacteria should be present in the cells of columnar epithelium in certain cases, seeing that their germs are always present in the old cells of squamous epithelium in the mouth. Horner: every five minutes, followed each time by a lump of ice." arrived," that cholera is essentially produced by a peculiar poison, the exact nature of wliich is not fully understood; that this poison is aided in its production and diffusion by certain local conditions, the chief of which is filth; that the action of this poison in the system is promoted by the presence in the blood of decomposing organic materials; that the effects of the poison are first manifested upon the ganglionic or organic system of nerves; that very generally, among the earliest and most important morbid effects which the paralyzed and deranged condition of the nervous force produces, are congestion and irritation of the nervous membrane of the alimentary canal, and profuse exhalations from its surface, leading to a watery diarrhoea, and at length to violent vomiting and purging of a nearly transparent fluid; that losses of the fluid portions of the blood together with the retention of certain excrementitious matters, aided, probably, by the peculiar cholera poison, so change the physical, chemical, and vital conditions of that fluid as to produce spasms of vessels, the cholera poison effects such changes in the blood and in the actions of the nervous system as to suspend the necessary life functions, and cause speedy as to afford no basis for a rule of practice in the ordinary forms of the disease." It will be manifest to the careful observer that, in the above conclusions, the author has ingeniously mixed up a few facts with a large amount of hypothesis, a coui-se which has never contributed to the advancement of positive knowledge.

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It principally attacks those of a middle age; females more frequently than males; and generally the unmarried; people in low life, who live much on milk and a farinaceous diet, rather than those in better condition; fluor albus. It becomes hypertrophied, loses its transparency, its surface becomes less polished, less villous, unequal, and covered with rugosities. The costal pleura was injected of a bright red colour; the lungs were hyperaemic, and the trachea and bronchial (spironolactone cream) tubes were injected, of a bright red, and contained reddish mucus. That the organs of generation have been occasionally affected with disorders resembling gonorrhoea and chancres, from time immemorial, was proved by Becket, Patin, Sanchez, Lombard, and many others before Astruc, who has embodied the evidences on this subject with considerable labour (spironolactone 25 mg uses).

Louis states that they are an invariable concomitant of tne intestinal disease which he considers as the anatomical character of true typhus.

In other instances there is general redness of the mucous membrane of the mouth, with all the characters of erythematous stomatitis, fever, vomiting, and diarrhoea.